A glycoprotein inhibitor of in vitro granulopoiesis associated with AIDS
نویسندگان
چکیده
منابع مشابه
A glycoprotein inhibitor of in vitro granulopoiesis associated with AIDS.
Patients infected with the human immunodeficiency virus (HIV) often present with neutropenia. To elucidate the mechanism(s) of this HIV-related neutropenia, we assessed the proliferative capacity of the granulocyte-macrophage progenitor cell (CFU-GM) from the bone marrow (BM) of 78 patients within the AIDS spectrum manifesting symptoms or signs related to HIV infection. Of these, 70 had a signi...
متن کاملBiochemical characterization of a leukemia-associated inhibitor (LAI) suppressing normal granulopoiesis in vitro.
Low-density (less than 1.077 g/ml) marrow or blood cells from patients with acute or chronic leukemia release a high molecular weight substance called "leukemia-associated inhibitor" (LAI) that reduces the fraction of normal marrow CFU-c in S-phase as measured with the 3H-TdR suicide technique. LAI from conditioned media or 3M KCl extracts of subcellular fractions behaved homogeneously on gel c...
متن کاملSuppression of normal granulopoiesis in vitro by a leukemia-associated inhibitor (LAI) of acute and chronic leukemia.
To determine if normal granulopoiesis can be suppressed by substances produced by cells from patients with leukemia. conditioned media from such cells were assayed for their ability to reduce the fraction of normal CFU-c in S-phase or inhibit cluster/colony formation in agar cultures. Low-density (<1 .077 g/ml) marrow or blood cells from patients with leukemia. but not from normals. were shown ...
متن کاملSuppression of Normal Granulopoiesis In Vitro by a Leukemia - Associated Inhibitor ( LA ! ) of Acute and Chronic Leukemia
To determine if normal granulopoiesis can be suppressed by substances produced by cells from patients with leukemia. conditioned media from such cells were assayed for their ability to reduce the fraction of normal CFU-c in S-phase or inhibit cluster/colony formation in agar cultures. Low-density (<1 .077 g/ml) marrow or blood cells from patients with leukemia. but not from normals. were shown ...
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ژورنال
عنوان ژورنال: Blood
سال: 1987
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v70.5.1267.1267